Chronic Obstructive Pulmonary Disease (COPD) exacerbation
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Guangzhou Medical College
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients with AECOPD and age-matched COPD-free controls, who were hospitalized in the First Affiliated Hospital of Guangzhou Medical College from June 2012 to December 2012, were recruited in this study. Written informed consent forms were obtained from all participants. The inclusion criteria were as follows: 1. >=50 years of age; 2. a smoking history of >=30 packs of cigarettes per year; 3. a medical history and results of physical examination, chest radiography, and pulmonary function test (PFT) consistent with the diagnosis of COPD (In particular, the result of PFT should include an FEV1/FVC ratio <=70%); 4. a COPD exacerbation event defined as an acute event characterized by significant worsening of the respiratory symptoms that led to a change in medication.
Exclusion criteria
Exclusion criteria: 1. patients with respiratory complications other than COPD; 2. patients with previous experience of tracheostomy, patients with head and neck cancer or with previous experience of head and neck surgery, and patients with CNS muscle pathology; 3. patients who underwent endotracheal incubation within 3 months; 4. patients with esophageal diseases, including cancer and stricture.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| BMI data, MRC scores, arterial blood gases and blood cell counts, chest radiography; | — |
Primary
| Measure | Time frame |
|---|---|
| Frequency of exacerbation events with 1 year (times); | — |
Countries
China
Contacts
Public ContactZeguang Zheng
Outcome results
None listed