depression
Conditions
Interventions
two:neuropsychological test
Sponsors
First Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patient group: 1. patients with a DSM-IV clinical criteria for major depressive episode; 2. patients who are experiencing their first depressive episode; 3. patients were between 18-45 years old, males and females; 4. patients who demonstrated a HAMD-17 (17-item Hamilton Depression Rating Scale) Score>=17; 5. right-handed; 6. education years>=9; 7. patients provided their written and informed consent. Control group: Age, gender and education level match the patient group and HAMD-17 scores were requested <=7.
Exclusion criteria
Exclusion criteria: Patients were excluded if they fell into any of the following categories: 1. had a history of serious physical, cerebral organic history or head injury; 2. mental retardation; 3. brain structural abnormalities; 4. uncooperative or can not effectively accomplish this experimenter; 5. drugs, alcohol or other psychotropic active substance abusers; 6. with cardiac pacemakers, insulin pumps, artificial heart valves and other metal in body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional connectivity within default state network (DMN); | — |
Secondary
| Measure | Time frame |
|---|---|
| the brain gray matter density;fractional anisotropy (FA) valus;regional homogeneity (ReHo) valus;ampli-tude of low frequency fluctuation,ALFF;cognitive function; | — |
Countries
China
Contacts
Public ContactHuang Manli
Outcome results
None listed