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Nrf2 inhibits oxidative stress and then ameliorates osteoarthritis

Nrf2 inhibits oxidative stress and then ameliorates osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-BPC-17013427
Enrollment
Unknown
Registered
2017-11-17
Start date
2018-01-01
Completion date
Unknown
Last updated
2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis

Interventions

Nrf2 activator:sulforphane
siRNA-Nrf2:si-RNA

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: the specimens of normal articular cartilage were acquired randomly from femoral neck fracture patients undergoing artificial hip replacement surgery.;Inclusion criteria: the specimens of normal articular cartilage were acquired randomly from femoral neck fracture patients undergoing artificial hip replacement surgery.

Exclusion criteria

Exclusion criteria: exclude the patients of RA, sPA and other inflammatory arthritis;Exclusion criteria: exclude the patients of RA, sPA and other inflammatory arthritis

Design outcomes

Primary

MeasureTime frame
CAT;HO-1;MDA;;CAT;HO-1;MDA;—

Contacts

Public ContactShao Fei;Shao Fei ;

Department of Rheumatology & Immunology, Shanghai Sixth People's Hospital;Department of Rheumatology & Immunology, Shanghai Sixth People's Hospital

shaophy0109@163.com;shaophy0109@163.com+86 18930174549;+86 18930174549

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026