systemic inflammatory response during cardiopulmonary bypass
Conditions
Interventions
CPB group:Without any intervention
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. The children have congenital ventricular septal defect (VSD) with or without atrial septal defect (ASD), aged 1~6 years old; 2. Children who have no operative contraindications; 3. No other special history:hematopoietic System Disease, hereditary metabolic disease and so on; 4. Parents and children understand research program and volunteer to participant in the program, then sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Children or their families refused to participate in this research projects; 2. Children with a history of recent upper respiratory tract infection; 3. Children who are undergoing immunosuppressive therapy or gene therapy; 4. Severe heart failure,heart function III to IV; 5. Other important organ dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CXCR4 mRNA;p-CXCR4;p-PLCß3;Gi-GTP;CXCR4 mean fluorescence intensity;Chemotactic index; | — |
Countries
China
Contacts
Public ContactShouyong Wang
Children's Hospital of Chongqing Medical University
Outcome results
None listed