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To screen pathogenic genes and pathways associated with slow transit constipation using whole-transcriptome sequencing technology

To screen pathogenic genes and pathways associated with slow transit constipation using whole-transcriptome sequencing technology

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-BON-17012324
Enrollment
Unknown
Registered
2017-08-10
Start date
2017-09-01
Completion date
Unknown
Last updated
2017-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

slow transit constipation

Interventions

after operation:Save they specimens

Sponsors

Suzhou Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) The identification of patient's diagnosis was based on standard exam procedures (physical examination, colonoscopy, colonic slow transit test) and/or a subsequent diagnostic laparotomy; (2) ability to read and understand the experiment, and to provide written informed consent.

Exclusion criteria

Exclusion criteria: (1) Gastrointestinal malignant tumor; (2) metabolic disease, such as diabetes mellitus (DM), gout, hyperlipoidemia (HL); (3) hematopathy, including all types of leukemia and anaemia; (4) any symptom of acute disease during the last 2 weeks, such as:febrile, cough, headache, nausea, vomit, stomachache, diarrhoea, hematuria; (5) momentous stress reaction during the last 2 weeks, such as psychic trauma and a large area of empyrosis; (6) use of specic drugs during the last 3 weeks, such as antibiotic (penicillins, quinolones, torlamician), hormone (deoxycortisone, dexamethasone), nonsteroid anti-in?ammatory drugs (NSAIDs; acenterine, fragrans, saridon, contac), among others; (7) medical treatments before current admission, such as radiotherapy, chemotherapy (because these treatments which invoke metabolic changes); (8) pregnant of lactating female.

Design outcomes

Primary

MeasureTime frame
mRNA, lncRNA, and circRNA expression on normal colon and diseased tissue of patients with slow transit constipation;

Countries

China

Contacts

Public ContactShuai Yan

Suzhou Hospital of Traditional Chinese Medicine

plmokn74123@163.com+86 18605125012

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026