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Tfh mediated IL-21–IL-21R/STAT3 pathway impaired in B cells results in decreased switching to IgG in children with PNS

Tfh mediated IL-21–IL-21R/STAT3 pathway impaired in B cells results in decreased switching to IgG in children with PNS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-BOC-17013730
Enrollment
Unknown
Registered
2017-12-06
Start date
2018-01-01
Completion date
Unknown
Last updated
2017-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary nephrotic syndrome

Interventions

PNS vs normal children:no

Sponsors

Children's hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. aged 1 year to 18 year; 2. meet the diagnos standard of primary nephrotic syndrome (consistent with the diagnostic criteria of the nephrology group, 2000.11. Zhuhai); 3. acquired Informed consent.

Exclusion criteria

Exclusion criteria: 1. secondary nephrotic syndrome; 2. Having basic diseases; 3. there are other reasones to stop the experiment.

Design outcomes

Primary

MeasureTime frame
B cell subsets;Tfh;memory Cell;—

Countries

China

Contacts

Public ContactQiu Li

Children's hospital of Chongqing Medical University

liqiu809@126.com+86 13708353809

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026