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The role and mechanism of gut microbiota for bariatric surgery in type 2 diabetes treatment

The role and mechanism of gut microbiota for bariatric surgery in type 2 diabetes treatment

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-BOC-17013139
Enrollment
Unknown
Registered
2017-10-28
Start date
2017-12-01
Completion date
Unknown
Last updated
2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

control:none

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All adult patients who underwent colonoscopy were not diagnosed with other diseases except type 2 diabetes mellitus. Collect surface samples from the ascending colon mucosa cavity by using colonoscopy. (1) Case group inclusion conditions: the diagnosis of type 2 diabetes was definitely diagnosed before colonoscopy; (2) control group inclusion conditions: without type 2 diabetes mellitus, and matched with age and sex of the case group. Diagnostic criteria of type 2 diabetes mellitus: (1) the symptoms of diabetes + random venous plasma glucose was 11.1mmol/L (200mg/dl); (2) abdominal venous plasma glucose was 7.0mmol/L (126mg/dl); (3) OGTT, 2h venous plasma glucose over 11.1mmol/L (200mg/dl).;Inclusion criteria: All adult patients who underwent colonoscopy were not diagnosed with other diseases except type 2 diabetes mellitus. Collect surface samples from the ascending colon mucosa cavity by using colonoscopy. (1) Case group inclusion conditions: the diagnosis of type 2 diabetes was definitely diagnosed before colonoscopy; (2) control group inclusion conditions: without type 2 diabetes mellitus, and matched with age and sex of the case group. Diagnostic criteria of type 2 diabetes mellitus: (1) the symptoms of diabetes + random venous plasma glucose was 11.1mmol/L (200mg/dl); (2) abdominal venous plasma glucose was 7.0mmol/L (126mg/dl); (3) OGTT, 2h venous plasma glucose over 11.1mmol/L (200mg/dl).;Inclusion criteria: All adult patients who underwent colonoscopy were not diagnosed with other diseases except type 2 diabetes mellitus. Collect surface samples from the ascending colon mucosa cavity by using colonoscopy. (1) Case group inclusion conditions: the diagnosis of type 2 diabetes was definitely diagnosed before colonoscopy; (2) control group inclusion conditions: without type 2 diabetes mellitus, and matched with age and sex of the case group. Diagnostic criteria of type 2 diabetes mellitus: (1) the symptoms of diabetes + random venous plasma glucose was 11.1mmol/L (200mg/dl); (2) abdominal venous plasma glucose was 7.0mmol/L (126mg/dl); (3) OGTT, 2h venous plasma glucose over 11.1mmol/L (200mg/dl).;Inclusion criteria: All adult patients who underwent colonoscopy were not diagnosed with other diseases except type 2 diabetes mellitus. Collect surface samples from the ascending colon mucosa cavity by using colonoscopy. (1) Case group inclusion conditions: the diagnosis of type 2 diabetes was definitely diagnosed before colonoscopy; (2) control group inclusion conditions: without type 2 diabetes mellitus, and matched with age and sex of the case group. Diagnostic criteria of type 2 diabetes mellitus: (1) the symptoms of diabetes + random venous plasma glucose was 11.1mmol/L (200mg/dl); (2) abdominal venous plasma glucose was 7.0mmol/L (126mg/dl); (3) OGTT, 2h venous plasma glucose over 11.1mmol/L (200mg/dl).;Inclusion criteria: All adult patients who underwent colonoscopy were not diagnosed with other diseases except type 2 diabetes mellitus. Collect surface samples from the ascending colon mucosa cavity by using colonoscopy. (1) Case group inclusion conditions: the diagnosis of type 2 diabetes was definitely diagnosed before colonoscopy; (2) control group inclusion conditions: without type 2 diabetes mellitus, and matched with age and sex of the case group. Diagnostic criteria of type 2 diabetes mellitus: (1) the symptoms of diabetes + random venous plasma glucose was 11.1mmol/L (200mg/dl); (2) abdominal venous plasma glucose was 7.0mmol/L (126mg/dl); (3) OGTT, 2h venous plasma glucose over 11.1mmol/L (200mg/dl).

Exclusion criteria

Exclusion criteria: According to the known factors that affect the composition of intestinal bacteria, exclude samples of any of the following circumstances: (1) infectious gastroenteritis within 2 months prior to colonoscopy; (2) antibiotics or probiotics were used in the first 4 weeks; (3) suffering from irritable bowel syndrome (IBS).;Exclusion criteria: According to the known factors that affect the composition of intestinal bacteria, exclude samples of any of the following circumstances: (1) infectious gastroenteritis within 2 months prior to colonoscopy; (2) antibiotics or probiotics were used in the first 4 weeks; (3) suffering from irritable bowel syndrome (IBS).;Exclusion criteria: According to the known factors that affect the composition of intestinal bacteria, exclude samples of any of the following circumstances: (1) infectious gastroenteritis within 2 months prior to colonoscopy; (2) antibiotics or probiotics were used in the first 4 weeks; (3) suffering from irritable bowel syndrome (IBS).;Exclusion criteria: According to the known factors that affect the composition of intestinal bacteria, exclude samples of any of the following circumstances: (1) infectious gastroenteritis within 2 months prior to colonoscopy; (2) antibiotics or probiotics were used in the first 4 weeks; (3) suffering from irritable bowel syndrome (IBS).;Exclusion criteria: According to the known factors that affect the composition of intestinal bacteria, exclude samples of any of the following circumstances: (1) infectious gastroenteritis within 2 months prior to colonoscopy; (2) antibiotics or probiotics were used in the first 4 weeks; (3) suffering from irritable bowel syndrome (IBS).

Design outcomes

Primary

MeasureTime frame
16S rRNA;

Countries

China

Contacts

Public ContactZhang Hong;Zhang Hong;Zhang Hong;Zhang Hong;Zhang Hong ;;;;

Shanghai Sixth People's Hospital;Shanghai Sixth People's Hospital;Shanghai Sixth People's Hospital;Shanghai Sixth People's Hospital;Shanghai Sixth People's Hospital

mingyi-hong@163.com;mingyi-hong@163.com;mingyi-hong@163.com;mingyi-hong@163.com;mingyi-hong@163.com+86 15921493799;+86 15921493799;+86 15921493799;+86 15921493799;+86 15921493799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026