chronic obstructive pulmonary disease
Conditions
Interventions
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. COPD patients: (1) Age >18 years; (2) Cigarette moking history>10 pack-years; (3) Pulmonary Function Test: FEV1/FVC18 years. (2)Cigarette smoking history>10 pack-years; (3) Pulmonary Function Test: FEV1/FVC>70%, FEV1/pred%>80%; 3. Healthy nonsmokers: (1) Aged >18 years. (2)Cigarette smoking history70%, FEV1/pred%>80%.
Exclusion criteria
Exclusion criteria: 1.With other respiratory disease such as athma, bronchiectasis, active tuberculosis, IPF, pulmonary hypetension, lobectomy, lung cancer. 2.Other significant disease such as congestive heart failure, unstable ischemic heart disease, renal failure, abnormal liver function, cancer. 3.AECOPD, lower respiratory tract infections or pneumonia within 6 weeks. 4.Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| phosphatidylinositol-3-kinase d;serine threonine kinase, Akt;histone deacetylase 2, HDAC2;interleukin-6;interleukin-8;tumor necrosis factor-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| NF--?B;AP-1;glucocorticoid receptor, GR;p38 MAPK;extracellular-signal regulated protein kinase, ERK;IL-1ß; | — |
Countries
China
Contacts
Public ContactChunting Tan
Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed