Infection caused by levofloxacin sensitive bacteria
Conditions
Interventions
Study group:single dose of 500mg levofloxacin tablet
Sponsors
The Second Affiliated Hospital of Zhejiang University Medical College
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy men aged 18~40 years; weighing more than 45kg, BMI (body weight kg/ height m^2) in the range of 18~25kg/m^2; no organ disease history and drug allergy history; no drug abuse and alcohol addiction; nearly 2 weeks without medication; with good communication between researchers, comply with the requirements of the entire study; informed agree, and signed informed consent.
Exclusion criteria
Exclusion criteria: Participated in other clinical trials in 2 months; donated or want to donate blood within 1 months at the end of the trial period or after the general examination; the general examination and blood pressure, heart rate and respiratory conditions are not qualified; clinical symptoms; laboratory examination (blood and urine routine, liver and kidney function and electrocardiogram) found in blood, heart, liver and kidney insufficiency; researchers think is not suitable to participate in the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative urinary excretion of levofloxacin;genotyes of transporters (MDR1, MRP2); | — |
Countries
China
Contacts
Public ContactQuan Zhou
The Second Affiliated Hospital of Zhejiang University Medical College
Outcome results
None listed