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The immune reaction mechanism and function research for E2 and E2R in the chronic hepatitis B maternal

The immune reaction mechanism and function research for E2 and E2R in the chronic hepatitis B maternal

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-BOC-16009446
Enrollment
Unknown
Registered
2016-10-16
Start date
2016-11-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic hepatitis B

Interventions

Case group:Nil
Control group:Nil

Sponsors

Shanghai first maternity and infant hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1) aged 18 to 45 years; 2) HBsAg and HBeAg positive, HBsAg positive duration > 6 months; 3) HBV DNA of 106 or higher cpies/mL; 4) ALT normal in early pregnancy; 5) have agreed to take part in the study, signed informed consent.

Exclusion criteria

Exclusion criteria: 1) the combination of HIV and other hepatitis virus, the TORCH infection; 2) has a history of abnormal liver function or relevant treatment; 3) the fatty liver, liver fibrosis and liver cirrhosis, liver cancer; 4) the merger of local disease; 5) the long-term use of hormone or immune inhibitors or antiviral treatment.

Design outcomes

Primary

MeasureTime frame
Estrogen and estrogen recepter;HBsAg, HBeAg, HBV DNA, liver function;Cytokines, immune cell types and functions;—

Countries

China

Contacts

Public ContactXu Chuanlu

Shanghai first maternity and infant hospital

xuchuanlu@foxmail.com+86 13661631960

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026