Sudden Sensorineural Hearing Loss
Conditions
Interventions
IMP:intratympanic methylprednisolone perfusion (0.5ml/day,40mg/ml)
Conventional:intravenous methylprednisolone 80mg/day×4day, 40mg/day×3day, 20mg/day×3day
Control:Not treatment
Sponsors
Nanjing Drum Tower Hosipital,Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: SSNHL is defined as a rapid hearing decline at least 30 dB in = 3 contiguous frequencies in 60 dB in the affected ear at the end of the conventional therapeutic regimen at our institution.
Exclusion criteria
Exclusion criteria: 1. Structural diseases, such as acoustic neuroma and stroke, are ruled out by head and neurotologic examination and magnetic resonance imaging. Patient has a history of ear disease or family history of hearing loss; 2. The patients exit the investigation; 3. The patients lose the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HDAC2;TNF-a;IL-8;Gulucocotoid receptor;H3, H4;PBMC in-vitro proliferation glucocortoid inhibition rate;pure tone average; | — |
Countries
China
Contacts
Public ContactShe Wandong
Nanjing Drum Tower Hosipital, Nanjing University Medical School
Outcome results
None listed