Rheumatoid Arthritis
Conditions
Interventions
RA patients:methotrexate
Healthy control (HC) individuals:Nil
Sponsors
The First Hospital, Jilin University, Changchun
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Plans to recruit 22 patients with VERA (<6 weeks of disease duration) at the in-patient service of the First Hospital of Jilin University (Jilin University, Changchun, China). Aged 20 to 90 years old. All the included patients fulfilled the diagnosis criteria established by the American College of Rheumatology and understand the content of the informed consent and is willing to cooperate with researchers to carry out the work. Healthy control (HC) individuals who matched the experimental patients in terms of age, gender, and ethnicity were recruited as the control group during the same period. None of the individuals in the control group had a history of any type of chronic inflammatory disease.
Exclusion criteria
Exclusion criteria: 1. treated with any disease-modifying antirheumatic drugs for any reason during the previous 6 months, and 2. diagnosed with a chronic inflammatory and autoimmune disease, such as diabetes, multiple sclerosis, inflammatory bowel disease, metabolic syndrome, hypertension, cardiovascular diseases, cancer, or recent infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bcl-6+ICOS+ Tfh cells; | — |
Countries
China
Contacts
Public ContactYanfang Jiang
The First Hospital of Jilin University, Changchun
Outcome results
None listed