Health Condition 1: E112- Type 2 diabetes mellitus with kidney complications
Conditions
Interventions
Intervention1: Individualised homoeopathic medicine plus concomitant care along with standard of care: Individualized homeopathic medication (IHM) following the method of the sixth edition of the Orga
Sponsors
D N De Homoeopathic Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.18 to 65 years. 2.Nephropathy Status Diagnosed diabetic nephropathy, characterized by albuminuria, UACR 30 to 3000 mg per g or persistent microalbuminuria. 3.Microalbuminuria range A2 30 to 300 mg per g and 4.eGFR range from G1 to G2, G1 more than 90milliliter per min 1.73 meter square G2 60 to 89 millilitre per min 1.73meter square 5.Diabetes Diagnosis Confirmed Type 2 Diabetes Mellitus. 6.Standard of Care Stability Patients must be on a stable, optimal dose of standard conventional treatment ACE inhibitors or ARBs, BP 120 by 80 mmHg, HbA1c control for at least 3 months prior to enrollment. 7.Homeopathic Feasibility Suitability for individualized homeopathic prescription clear symptom totality. 8.Informed Consent Willingness to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.End-Stage Renal Disease ESRD Patients on dialysis hemodialysis or peritoneal or having undergone renal transplantation. 2.Uncontrolled diabeties mellitus HbA1c more than 9percent with diabetic nephropathy. 3.Rapidly Progressive Renal Disease eGFR less than 15 to 20 milliliter per min 1.73meter square stages 4 to 5. 4.Diabetic nephropathy patients suffering from uncontrolled diabetes mellitus HbA1c more than 8 to 9 percent 5.Severe Comorbidities Active malignancy, unstable cardiovascular disease MI within 3 months, severe heart failure, or severe chronic obstructive pulmonary disease. 6.Recent Medication Changes Changes in diabetes medication or blood pressure medication within the last 4 weeks. 7.Other Causes of Renal Dysfunction Nephropathy not caused by diabetes polycystic kidney disease. 8.Pregnancy or Lactation Pregnant or lactating women. 9.Psychiatric Disorders Active psychiatric conditions that might hinder compliance with the N of 1 protocol. 10.Concurrent Complementary Therapy Simultaneous homeopathic treatments. 11.Participants with type I DM or secondary diabetes pancreatic, steroid induced.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine albumin to creatinine ratioTimepoint: At baseline every 28 days up to 168 days | — |
Secondary
| Measure | Time frame |
|---|---|
| eGFR calculationsTimepoint: At baseline every 28 days up to 168 days;Blood Parameters fasting blood sugar, postprandial blood sugar, serum creatinineTimepoint: At baseline every 28 days up to 168 days;Blood Parameters HbA1c percentage and Haemoglobin levelsTimepoint: At baseline mid study day 84, and at the end of the study day 168.;Modified Diabetes Quality of Life 17 questionnaireTimepoint: At baseline every 28 days up to 168 days | — |
Countries
India
Contacts
Public ContactDr Shaikh Mizba Ainul
D N De Homoeopathic Medical College and Hospital
Outcome results
None listed