Health Condition 1: N51- Disorders of male genital organs in diseases classified elsewhere
Conditions
Interventions
Intervention1: Autologous Platelet-Rich Plasma: Injection of platelet-rich plasma in the scrotum around the spermatic cord. Two-injection protocol will be employed:
Injection site one with 3 mL of a
Sponsors
AIIMS Raipur
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male patients aged 18 to 60 years. 2. Chronic scrotal content pain involving the testis, epididymis, or spermatic cord persisting for 3 months or more. 3. Localized tenderness over the spermatic cord and or paratesticular structures on clinical examination. 4. Positive diagnostic spermatic cord block, defined as equal to or more than 50 percent temporary pain relief, indicating peripheral cord mediated pain. 5. Scrotal ultrasonography excluding surgically correctable pathology, with findings not requiring immediate operative intervention.
Exclusion criteria
Exclusion criteria: 1. Evidence of central sensitization or referred pain, including predominant lumbar spine, hip, or abdominal pathology contributing to symptoms. 2. Active genitourinary infection, testicular malignancy, or suspicious scrotal lesion. 3. Untreated varicocele or other surgically correctable cause of scrotal pain. 4. Prior microsurgical denervation of the spermatic cord or other definitive nerve-ablative procedures. 5. Coagulation disorders, platelet dysfunction, or current anticoagulant therapy that cannot be safely discontinued.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of procedure related adverse events infection, hematoma, worsening pain, testicular atrophyTimepoint: at intervention, 3-month, and 6-month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in pain intensity measured by Visual Analog Scale at baseline, 1 month, 3 months, and 6 months 2. Reduction in analgesic medication usage: Proportion of patients achieving equal or more than 50 percent reduction in analgesic medication use 3. Patient global impression of improvement PGI-I Timepoint: at baseline, 1 month, 3 months, and 6 months | — |
Countries
India
Contacts
Public ContactSatyadeo Sharma
AIIMS Raipur
Outcome results
None listed