Health Condition 1: -
Conditions
Interventions
Intervention1: Millet Enriched Enteral Nutrition: Intervention group will receive a millet-enriched enteral nutrition formula containing foxtail millet and finger millet as the primary cereal compone
Sponsors
All India Institute of Medical Sciences, Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 years or older. 2. Expected ICU stay 72 hours or longer. 3. Hemodynamically stable. 4. Clinical decision to start enteral nutrition within 24 to 48 hours of ICU admission. 5. Able to receive gastric or post pyloric tube feeding. 6. Patients admitted to the ICU for any acute medical, surgical, or neurological illness.
Exclusion criteria
Exclusion criteria: 1. Conditions where enteral feeding is contraindicated, including bowel obstruction, bowel ischemia, active gastrointestinal bleeding, recent major gastrointestinal surgery, severe ileus, abdominal compartment syndrome, or high output proximal gastrointestinal fistula. 2. Known neuromuscular disorders e.g., myasthenia gravis, muscular dystrophy, motor neuron disease, Guillain Barre syndrome. 3. Pre existing muscle wasting or sarcopenia prior to ICU admission. 4. Known allergy or intolerance to millet or millet based products. 5. Body Mass Index less than 18.5 kilograms per square metre.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle wasting assessed by change in quadriceps muscle thickness measured using ultrasonography.Timepoint: Baseline Day 1, Day 7, and Day 14 or ICU discharge, whichever occurs earlier. | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional recovery assessed using the ICU Mobility Scale.Timepoint: Baseline Day 1, Day 7 and Day 14 or until ICU discharge, whichever occurs earlier.;Handgrip strength measured using a hydraulic hand dynamometer.Timepoint: Baseline Day 1, Day 7, and Day 14 or ICU discharge, whichever occurs earlier.;Gastrointestinal intolerance to enteral nutrition.Timepoint: Assessed daily during ICU stay until Day 14 or ICU discharge, whichever occurs earlier.;Duration of invasive mechanical ventilation.Timepoint: Up to ICU discharge or Day 28, whichever occurs earlier.;ICU length of stay.Timepoint: Up to ICU discharge or Day 28, whichever occurs earlier.;ICU mortality.Timepoint: Up to ICU discharge or Day 28, whichever occurs earlier. | — |
Countries
India
Contacts
Public ContactPriya Sharma
AIIMS Jodhpur Rajasthan
Outcome results
None listed