Health Condition 1: R112- Nausea with vomiting, unspecified
Conditions
Interventions
Intervention1: Ondansetron and Dexamethasone: Ondansetron 0.1 mg/kg + Dexamethasone 0.15 mg/kg (maximum to 8 mg) intravenously given ,
diluted with normal saline to a total volume of 10 ml, administe
Sponsors
Government Medical college and Hospital , sector 32-B, Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Surgery under general anesthesia less than 3 hours duration. 2. Non smoker. 3. American Society of Anesthesiologists ASA Grade I or II.
Exclusion criteria
Exclusion criteria: 1. Patient taking an opioid regularly. 2. Patient receiving radiation or chemotherapy. 3. Patients having recurrent or persistent nausea. 4. Patients with renal impairment where serum creatinine is greater than 1.6 mg dl or hepatic impairment where liver enzymes are more than twice the normal value. 5. History of allergy to 5HT3 receptor antagonist. 6. Patients having diabetes or cardiovascular disease or respiratory disease or renal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Post Operative Nausea and Vomiting within the first 24 hours among the 3 groupsTimepoint: Assessed in PACU every half an hour for 2 hours and at intervals of 2 to 6 hours and 6 to 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of PONV assessed by Visual Analogue Scale 0 to 10Timepoint: Assessed in PACU every half an hour for 2 hours and at intervals of 2 to 6 hours and 6 to 24 hours postoperatively;Adverse effects related to antiemetic drugsTimepoint: Observed and recorded within the first 24 hours postoperatively;Requirement of rescue antiemetic number of patients requiring rescue medicationTimepoint: Within the first 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr Dheeraj Kapoor
Government Medical College and Hospital, Sector 32-B, Chandigarh
Outcome results
None listed