Health Condition 1: C539- Malignant neoplasm of cervix uteri, unspecified
Conditions
Interventions
Intervention1: Hypofractionated Chemoradiation followed by Brachytherapy: Arm B - will consist of External Beam Radiotherapy (EBRT) to the pelvis at a dose of 37.5Gy/15# 5 days a week over 3 weeks at
Sponsors
All India Institute of Medical Sciences, AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 to 65, Biopsy proven Carcinoma Cervix, Clinically and radiologically disease-free 6 months after RT, ECOG PS less than equal to 2, Willing to participate and provide informed consent, Sexually active or willing to resume sexual activity post-treatment, Stage IB3 to IIIC1, The patient should be able to understand and follow instructions.
Exclusion criteria
Exclusion criteria: Prior pelvic surgery or re-irradiation that alters vaginal anatomy significantly, Severe psychiatric illness or cognitive impairment, Pregnancy or lactation, Medical contraindication to sexual activity, Refusal to participate in rehabilitation activities,Gross HDUN
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of Sexual function at 6 months post definitive and hypofractionated Radiotherapy by Female Sexual Function Index questionnaire.Timepoint: Sexual function will be assessed at 6 months post-treatment completion. | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal toxicity assessment Dosimetric analysis of Vaginal dose Corelation between Vaginal dosimetry and Sexual FunctionTimepoint: 6 months post treatment | — |
Countries
India
Contacts
Public ContactSibika Malla
National Cancer Institute,AIIMS
Outcome results
None listed