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Effects of genetic polymorphism on opioid requirements in opioid naive patients after surgery under general anaesthesia.

Analysis of postoperative opioid analgesic requirements in opioid naive patients with uridine 5 diphosphate glucoronosyl transferase polymorphism UGT2B7 and human mu opioid receptor gene polymorphism OPRM1 A118G undergoing surgery under general anaesthesia. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/07/114054
Enrollment
260
Registered
2026-07-15
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil

Sponsors

Rajendra Institute of Medical Sciences Ranchi
Lead Sponsor
Not required
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade 1 and 2, patients aged 18 to 75 years posted for elective GI or Gynecological or urological or cardiac surgeries under general anaesthesia. The anticipated duration of surgery should be less than 3 hours and uneventful.

Exclusion criteria

Exclusion criteria: Patients with severe infection, liver or kidney disease, congenital disorder, blunt or penetrating injury abdomen, scoliosis or kyphosis, obesity or underweight. Patients undergoing surgeries like neurosurgery, oncosurgery, cancer patients, patients who are already taking opioids in any form, pregnant patients and patients with neurological illnesses. Any major complication during surgery such as massive blood loss, the requirement of inotropic support, duration extending to more than 3 hours and requirement of mechanical ventilation during the postoperative period will be excluded.

Design outcomes

Primary

MeasureTime frame
To measure total opioid requirement in 24 hours, postoperatively.Timepoint: To measure total opioid requirement in 24 hours, postoperatively.

Secondary

MeasureTime frame
To analyse the incidence of postoperative nausea and vomiting. To analyse sedation scores. Timepoint: To measure total opioid requirement in 24 hours, postoperatively.

Countries

India

Contacts

Public ContactDr Tushar Kumar

RIMS Ranchi.

drpradipkb@gmail.com9472758699

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026