Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention1: Protocolized Arterial blood gas guided hemodynamic optimization: Participants in the intervention group will receive a structured arterial blood gas guided postoperative hemodynamic opt
Sponsors
Sri Ramachandra Institute of Higher Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing elective, isolated off-pump coronary artery bypass grafting surgery. Adult patients aged 30 years or older. Patients undergoing either single-vessel or multi-vessel off-pump coronary artery bypass grafting procedures. Patients admitted to the postoperative cardiac intensive care unit following surgery.
Exclusion criteria
Exclusion criteria: Emergency cardiac surgery. On-pump coronary artery bypass grafting procedures. Minimally invasive cardiac surgery. Combined cardiac procedures, including valve surgery, aortic surgery, or redo cardiac surgery. Severe preoperative cardiac dysfunction, defined as left ventricular ejection fraction of 35 percent or less, requirement for inotropic or vasopressor support, or preoperative mechanical ventilation. End-stage renal disease requiring chronic dialysis. Requirement for postoperative mechanical circulatory support, including intra-aortic balloon pump, extracorporeal membrane oxygenation, or ventricular assist devices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of vasoactive support during the postoperative period following OPCAB surgery. Postoperative oxygenation assessed using ABG derived indices such as Alveolar arterial oxygen gradient and Oxygenation Index. Timepoint: At ICU admission, 2 hours, 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| By assessing the incidence and severity of strong ion gap to determine potential reduction. The hemodynamic and respiratory outcomes will be improved. Minimizing the postoperative complications like acute kidney injury and requirement of renal replacement therapy. The overall clinical improvement like ICU length of stay, hospital stay and ICU mortality will be increased.Timepoint: At ICU admission, 2 hours, 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours postoperatively. | — |
Countries
India
Contacts
Public ContactDr B Ranjith Karthekeyan
Sri Ramachandra Institute of Higher Education and Research
Outcome results
None listed