Health Condition 1: I999- Unspecified disorder of circulatory system
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
All India Institute of Medical Sciences, Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 0 to 18 years undergoing elective or emergency on pump cardiac surgery with cardiopulmonary bypass at AIIMS Jodhpur. Written informed consent obtained from the parent or legally acceptable representative. Age appropriate assent obtained from children wherever applicable as per IEC and ICMR guidelines.
Exclusion criteria
Exclusion criteria: Pre existing renal dysfunction, serum creatinine greater than 1.5 times the age adjusted normal value. Re operations. Single ventricle physiology or uncorrected cyanotic lesions with baseline SpO2 less than 75 percent. Refusal of consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cardiac surgery associated acute kidney injury within 72 hours after pediatric cardiac surgery diagnosed according to KDIGO criteria and its prediction using indexed oxygen deliveryTimepoint: 24 hours, 48 hours and 72 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of renal near infrared spectroscopy parameters for predicting postoperative AKITimepoint: Baseline before induction of anaesthesia & continuous intraoperative monitoring until the end of surgery. Nadir renal SO2, time under threshold & area under threshold calculated from complete intraoperative recording. AKI assessed at 24, 48 & 72 hours postoperatively.;Association between intraoperative oxygen extraction ratio during cardiopulmonary bypass & postoperative AKI.Timepoint: Baseline after initiation of CPB, 10 minutes after aortic cross clamp, nadir cooling, rewarming at 35 degree Celsius, 10 minutes after aortic unclamping, end of CPB. AKI assessed at 24, 48 & 72 hours postoperatively.;Incidence & severity of postoperative AKI according to KDIGO classificationTimepoint: At 24, 48 & 72 hours postoperatively.;Duration of postoperative mechanical ventilationTimepoint: From surgery until extubation;Length of ICU stayTimepoint: From ICU admission until ICU discharge;Length of hospital stayTimepoint: From surgery until hospital discharge | — |
Countries
India
Contacts
Public ContactDr Gaurav Chaudhary
All India Institute of Medical Sciences, Jodhpur
Outcome results
None listed