Health Condition 1: M171- Unilateral primary osteoarthritisof knee
Conditions
Interventions
Intervention1: Carbohydrate drink: 400 mL of solution providing ~50g of carbohydrate
2-4 hours prior to surgery
Control Intervention1: Clear fluid: 400 mL of clear warm fluid
2-4 hours prior to surgery
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults planned for elective unilateral total knee arthroplasty. 2. Patients providing written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with previous lower limb surgery, inflammatory arthritis, contraindications to regional anaesthesia, known gastroesophageal reflux disease or gastric emptying disorders, autonomic neuropathy, cognitive disorders MMSE less than 24, and HbA1c more than 8 percent within 2 months of surgery, BMI more than 35 2. Patients on insulin therapy 3. Patients unwilling for participation in the study or not giving consent for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether preoperative carbohydrate loading reduces postoperative insulin resistance compared with clear fluids prior to TKA.Timepoint: To determine whether preoperative carbohydrate loading reduces postoperative insulin resistance compared with clear fluids prior to TKA on post-operative day 1 and day 2 | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare glucose variability, fasting glucose, C-peptide, GLP-1, IL-6, & morning cortisol between groupsTimepoint: Preoperative & post operative day 0;To record preoperative hunger & thirst scores To assess postoperative gastric emptying & measure gastric residual volume. To document incidence of postoperative nausea & vomitingTimepoint: Preoperative Post operative day 0 Post operative day 1 & 2;To measure preoperative & postoperative pain VAS & anxiety scoresTimepoint: Postoperative days 0;Knee range of motion preoperatively, POD1, 6-week, & 3-month follow up. Timed Up & Go TUG test preoperative & 3 months follow up Oxford Knee Score OKS preoperative & 3 months follow up EQ5D score preoperative & 3 months follow up Two minute walk test preoperative & 3 months follow upTimepoint: 6 weeks & 3 months;Length of hospital stay 90-day readmission and postoperative complication ratesTimepoint: | — |
Countries
India
Contacts
Public ContactDr Sahil Batra
AIIMS, Delhi
Outcome results
None listed