Comparison of air, saline, and lidocaine used to inflate the endotracheal tube cuff and their effects on throat discomfort in patients undergoing laparoscopic surgery under general anaesthesia.

A randomized comparative study to evaluate effect of tracheal tube cuff pressure on tracheal mucosa by using air, saline and lidocaine on tracheal tube cuff inflation during laparoscopic surgeries under General Anaesthesia at SMS Medical College and associated group of hospitals, Jaipur - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113887

Enrollment

Registered

2026-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lidocaine: Effect of lidocaine on tracheal cuff pressure measured by using a trasducer when pilot cuff is inflated with it at three different time period being T1- just after intubation

Eligibility

Inclusion criteria

Inclusion criteria: Patients who 1.consent to be part of this study 2.are undergoing elective laparoscopic resection under general anesthesia with orotracheal intubation were chosen for the study 3.are adults aged 18to65 years 4.have an ASA physical status I to III

Exclusion criteria

Exclusion criteria: Patients who 1.have asthma, chronic obstructive pulmonary disease or psychiatric disorders 2.have a BMI less than 19 kg/m2 or more than 30 kg /m2 3.have a Mallampati Classification III or IV 4.have preexisting sore throat, hoarseness, cough, or hemorrhage of laryngeal mucosa 5.were intubated more than once during anaesthesia induction 6.experienced bucking during surgery 7.had delayed emergence-inability to regain an adequate level of consciousness, unresponsiveness, or deep sedation for over 60 min from the last administration of anaesthetic agents 8.required reintubation within 48h after extubation

Design outcomes

Primary

Measure	Time frame
To determine the effect of cuff inflation with air, saline and lidocaine on tracheal tube cuff pressure during laparoscopic surgeries under general anaesthesia. Timepoint: T1- after intubation but before creating pneumoperitoneum, T2- after 15 mins of creating pneumoperitoneum, T3- after exsufflation but before intubation.	—

Secondary

Measure	Time frame
1. To determine the Tracheal Diameter-TD and Endotracheal Tube Cuff Diameter-CD on the selected participants using the ultrasound probe 2. To determine the correlation-if any, between the TD and CD measured by the ultrasound probe intraoperatively with the corresponding Tracheal Tube Cuff Pressure at various time intervals. 3. To assess the incidence of post-operative complications of using the above stated materials for inflation of endotracheal tube cuffTimepoint: T1- after intubation but before creating pneumoperitoneum. T2- after 15 mins of creating pneumoperitoneum. T3- after exsufflation but before intubation. Post op complication noted at 0hr,2hr,12hr and 24hr	—

Measure

Time frame

1. To determine the Tracheal Diameter-TD and Endotracheal Tube Cuff Diameter-CD on the selected participants using the ultrasound probe 2. To determine the correlation-if any, between the TD and CD measured by the ultrasound probe intraoperatively with the corresponding Tracheal Tube Cuff Pressure at various time intervals. 3. To assess the incidence of post-operative complications of using the above stated materials for inflation of endotracheal tube cuffTimepoint: T1- after intubation but before creating pneumoperitoneum. T2- after 15 mins of creating pneumoperitoneum. T3- after exsufflation but before intubation. Post op complication noted at 0hr,2hr,12hr and 24hr

—

Countries

India

Contacts

Public ContactDr. Aakansha Mehra

SMS Medical College, Jaipur

drindu.verma@gmail.com9413622967

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026