Study to determine the effective dose of noradrenaline infusion to prevent low blood pressure after spinal anaesthesia in women undergoing emergency cesarean section

ED50 calculation of noradrenaline infusion in prevention and treatment of spinal induced hypotension in patients undergoing emergency LSCS: A prospective, open label dose response trial using up-down sequential allocated method - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113876

Enrollment

Registered

2026-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: Noradrenaline infusion: Intravenous noradrenaline infusion through a syringe infusion pump will be started at 1.6 mcg/min(80 mcg noradrenaline in normal saline 0.9% w/v 50 mL) at the en

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing emergency LSCS under spinal anaesthesia ASA 2/3

Exclusion criteria

Exclusion criteria: Contraindication to spinal anaesthesia Patient refusal Pre existing hypertension, pre eclampsia, eclampsia Cardiovascular, renal or endocrine disorders Allergy to study drug Known fetal anomalies

Design outcomes

Primary

Measure	Time frame
ED50 of noradrenaline infusion for prevention of spinal induced hypotension following spinal anaesthesia in emergency LSCSTimepoint: Blood pressure, pulse rate and oxygen saturation will be monitored at base line, post spinal, 3 min,6 min,10 min and thereafter at 5 min interval till the delivery of baby or 15 min after spinal anaesthesia whichever is earlier	—

Secondary

Measure	Time frame
ED95 of noradrenaline for prevention of post spinal hypotension Incidence of nausea vomiting shivering Neonatal outcomes APGAR score at 1 & 5 minTimepoint: 0,3,6,10,15 min or delivery of baby APGAR score at 1 & 5 min	—

Countries

India

Contacts

Public ContactDr Mansi Negi

R.N.T. Medical college and MB Hospital, Udaipur

Vbedimd@gmail.com9829025373

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026