To compare the effects of two different anaesthesia techniques on memory, language, and executive functions following pituitary tumour removal via the nose

The effect of total intravenous anaesthesia TIVA versus inhalational anaesthesia IA on postoperative Cognitive function in patients undergoing endoscopic trans-nasal trans-sphenoidal TNTS excision of pituitary adenoma A randomised controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113837

Enrollment

Registered

2026-07-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D352- Benign neoplasm of pituitary gland

Interventions

Intervention1: TOTAL INTRAVENOUS ANAESTHESIA WITH PROPOFOL: Propofol administered using the Schneider TCI protocol, with effect-site concentration (Ce) maintained at 2.5 4 g/mL, titrated to a BIS val

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1-3 Patients, aged between 18-70 years, diagnosed with pituitary adenoma: both functional or non-functional tumours planned for endoscopic trans-nasal, trans-sphenoidal excision.

Exclusion criteria

Exclusion criteria: Patients with pituitary adenoma undergoing combined transcranial and endoscopic approach for excision of tumour Major psychiatric illness or neurodegenerative disorders Patients with chronic renal failure stage 3 and above or liver failure undergoing endoscopic TNTS excision Patients with Mutism or Deafness or Blind or Intellectual disturbances. Patients with Cushings syndrome All patients with symptomatic hyponatremia with Sodium levels less than 125 meq per dL Patients with long standing diabetes more than 10 years with uncontrolled sugars Patient with history of microvascular diseases like ischaemic heart disease more than 10 years

Design outcomes

Primary

Measure	Time frame
Perioperative change in MoCA score - Pre surgery versus Post surgery between the groups - TIVA with Propfol versus Inhalational Anaesthesia with Sevoflurane - in patients undergoing pituitary adenoma excision via the transnasal transsphenoidal route using the Montreal Cognitive Assessment screening tool.Timepoint: Cognitive tests shall be done at Preoperative baseline Post operative day 7 or At discharge post surgery Post operative 3rd month followup	—

Measure

Time frame

Perioperative change in MoCA score - Pre surgery versus Post surgery between the groups - TIVA with Propfol versus Inhalational Anaesthesia with Sevoflurane - in patients undergoing pituitary adenoma excision via the transnasal transsphenoidal route using the Montreal Cognitive Assessment screening tool.Timepoint: Cognitive tests shall be done at Preoperative baseline Post operative day 7 or At discharge post surgery Post operative 3rd month followup

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Secondary

Measure	Time frame
To study the incidence of perioperative neurocognitive disorders using MocATimepoint: Cognitive tests shall be done at Preoperative baseline Post operative day 7 or At discharge post surgery Post operative 3rd month followup ;To study the incidence of perioperative neurocognitive disorders using neurocognitive battery of testsTimepoint: Cognitive tests shall be done at Preoperative baseline Post operative day 7 or At discharge post surgery Post operative 3rd month followup ;To study the incidence of preoperative neurocognitive disorders using MoCA Timepoint: Cognitive tests shall be done at Preoperative baseline ;To study the incidence of preoperative NCD using the neurocognitive battery of testsTimepoint: Cognitive tests shall be done at Preoperative baseline;To determine various perioperative risk factors which include preoperative, intraoperative and postoperative factors associated with the occurrence of neurocognitive disordersTimepoint: Pre operative, intraoperative and post operative period	—

Measure

Time frame

To study the incidence of perioperative neurocognitive disorders using MocATimepoint: Cognitive tests shall be done at Preoperative baseline Post operative day 7 or At discharge post surgery Post operative 3rd month followup ;To study the incidence of perioperative neurocognitive disorders using neurocognitive battery of testsTimepoint: Cognitive tests shall be done at Preoperative baseline Post operative day 7 or At discharge post surgery Post operative 3rd month followup ;To study the incidence of preoperative neurocognitive disorders using MoCA Timepoint: Cognitive tests shall be done at Preoperative baseline ;To study the incidence of preoperative NCD using the neurocognitive battery of testsTimepoint: Cognitive tests shall be done at Preoperative baseline;To determine various perioperative risk factors which include preoperative, intraoperative and postoperative factors associated with the occurrence of neurocognitive disordersTimepoint: Pre operative, intraoperative and post operative period

—

Countries

India

Contacts

Public ContactDr Ramamani Mariappan

Christian Medical College Vellore

ramamani@cmcvellore.ac.in9443753184

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026