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A study to evaluate how slow and fast administration of laughing gas affects childrens pain, memory, alertness during and after dental treatment.

Neurocognitive alertness and recovery following slow and rapid induction of nitrous oxide-oxygen inhalational sedation in children: A Dental Perspective - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/07/113792
Enrollment
44
Registered
2026-07-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R411- Anterograde amnesia

Interventions

Intervention1: Rapid nitrours oxide induction: Nitrous oxide concentration increased rapidly according to study protocol until the desired sedation level is achieved. Control Intervention1: Slow nitro

Sponsors

Sasikala M Nair
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients requiring an invasive procedure and administration of LA. Children with mild to moderate dental anxiety. ASA physical status I or II.

Exclusion criteria

Exclusion criteria: Children requiring deep sedation or general anaesthesia. Children with acute respiratory illness or contraindications to nitrous oxide. Children unable to tolerate nasal hood placement.

Design outcomes

Primary

MeasureTime frame
To compare the effects of slow and rapid induction techniques on neurocognitive alertness and recovery.Timepoint: Preoperatively Intraoperatively Immediate Postoperatively 2 hour Postoperatively—

Secondary

MeasureTime frame
To assess changes in anxiety levels at different stages of sedation and recovery.Timepoint: Preoperatively Intraoperatively Immediate Postoperatively 2 hours Postoperatively;To evaluate the degree of amnesia associated with nitrous oxide sedation.Timepoint: Preoperatively Intraoperatively Postoperatively;To assess pain perception during dental procedures performed under sedation.Timepoint: Intraoperatively;To determine whether the induction technique influences cognitive and behavioural responses during and after sedation.Timepoint: Preoperatively Postoperatively—

Countries

India

Contacts

Public ContactSasikala M Nair

Institute of dental studies and technologies

aakansha09s.as@gmail.com9072975421

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026