Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: INJ DEXMEDETOMIDINE: dexmedetomidine 1 mcg/kg as a loading dose infused over 10 minutes prior to
induction, followed by a maintenance infusion of 0.5 mcg/kg/hour throughout the surgical
Sponsors
OMKAR SIDDHLING DEOGAONKAR
Eligibility
Inclusion criteria
Inclusion criteria: ASA Physical Status I II and III Elective lumbar spine surgery under general anaesthesia Body weight 40 to 90 kg Ability to understand and use the Visual Analogue Scale for pain assessment Written informed consent obtained
Exclusion criteria
Exclusion criteria: Patients with known hypersensitivity or contraindication to dexmedetomidine or magnesium sulfate heartPatients with significant cardiac conduction abnormalities like block sick sinus syndrome severe bradycardia Severe hepatic or renal impairment Chronic opioid or analgesic use more than 3 months Pregnancy or lactation Emergency surgeries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic stability assessed by Mean Arterial Pressure compared between the dexmedetomidine and magnesium sulfate groupsTimepoint: Baseline Post-induction Post-intubation Every 15 minutes intraoperatively At extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate systolic blood pressure diastolic blood pressureTimepoint: Baseline Post-induction Post-intubation Every 15 minutes intraoperatively At extubation;Postoperative pain using the Visual Analogue ScaleTimepoint: 0, 1, 2, 4, 6, 12, 16, 20, and 24 hours.;Total rescue analgesic requirementTimepoint: IN 24 hr after surgery | — |
Countries
India
Contacts
Public ContactDR SUJAY J N
SRI SIDDHARTHA MEDICAL COLLEGE AND HOSPITAL TUMKUR
Outcome results
None listed