Health Condition 1: M179- Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention1: Intravenous vitamin C: Intravenous vitamin C 5 g in 100 ml normal saline, administered 1 hour before shifting to OT
Intervention2: Liposomal vitamin C 5 g orally: Liposomal vitamin C 5
Sponsors
Research section, AIIMS, Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 65 years Undergoing unilateral primary TKA ASA Physical Status 1-3 Use of tourniquet during surgery Informed consent obtained
Exclusion criteria
Exclusion criteria: Known hypersensitivity to vitamin C Renal insufficiency (eGFR less than 30 ml per min) History of oxalate kidney stones Active infection autoimmune inflammatory disease Participation in another interventional trial within 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reducing MDA levels at 5 minuteTimepoint: at 5 minute after deflating torniquet | — |
Secondary
| Measure | Time frame |
|---|---|
| Reducing MDA Malondialdehyde levels Serum Vitamin C IL 6 Hypoxanthine Postoperative pain by VAS score Functional recovery by Knee Society Score Delirium Incidence of CRPS Timepoint: MDA levels at baseline 30 minutes of torniquet deflation Level of serum Vitamin C IL 6 Hypoxanthine at baseline 5 minutes postreperfusion & 30 minutes post torniquet deflation Postoperative pain by VAS score at 0 6 12 24 hours & 3 months postoperatively Functional recovery by Knee Society Score preoperatively & at 3 months Delirium 24 hours postoperatively Incidence of CRPS 3 months postoperatively | — |
Countries
India
Contacts
Public ContactNeha Garg
All India Institute Of Medical Sciences, Delhi, India
Outcome results
None listed