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Assessment of Caspase-1 Levels in Healthy Individuals and Patients with Gum Disease with and Without Diabetes a Cross-sectional Study

Comparative Evaluation of Serum and Gingival Crevicular Fluid Levels of Caspase 1 in Periodontally Healthy Subjects Periodontitis Patients with and without Diabetes - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/07/113758
Enrollment
90
Registered
2026-07-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil Control Intervention2: Nil: Nil Control Intervention3: Nil: Nil

Sponsors

Sri Sai College of Dental Surgery
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group A (Healthy group): 15 systemically healthy subjects aged 25-60 years with clinically healthy periodontium. Group B (Periodontitis group): 15 systemically healthy patients aged 25-60 years with moderate to severe periodontitis with at least 5 teeth having PPD5mm CAL4mm bleeding on probing and radiographic evidence of bone loss. Group C (Periodontitis with Diabetic group): 15 Type II Diabetes Mellitus patients aged 25-60 years (with HbA1C values above 6.5 FBS levels above 120mgdl) with periodontitis with at least 5 teeth having PPD 5mm and CAL4mm bleeding on probing and radiographic evidence of bone loss.

Exclusion criteria

Exclusion criteria: 1. Patients with any known systemic disease (other than diabetes) which can alter the course of periodontal disease. 2. Patients who have undergone periodontal treatment in past 6 months. 3. Patients having the habit of smoking and tobacco chewing. 4. Patients with the history of any recent infections. 5. Pregnant and lactating women. 6. Patients with Aggressive periodontitis 7. Patients with a history of antibiotic or anti-inflammatory drug intake in the past six months 8. Patients on treatment with steroids 9. Patients with congenital abnormalities

Design outcomes

Primary

MeasureTime frame
Serum and Gingival Crevicular Fluid Caspase 1 levels in Periodontally Healthy Subjects Periodontitis Patients and Periodontitis Patients with Type 2 Diabetes MellitusTimepoint: Baseline—

Secondary

MeasureTime frame
Correlation of Serum and Gcf Caspase-1 levels with clinical periodontal parameters (PI,MGI,BI,PPD,CAL) and comparsion among the three study groups.Timepoint: Baseline—

Countries

India

Contacts

Public ContactMansanpally Shravika

Sri Sai College of Dental Surgery

dr.preetikrishnan@gmail.com9561074859

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026