Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Ramifentanyl
: Induction dose of 2 g/kg, followed by a maintenance infusion of 0.05 0.2 g/kg/min, started immediately after induction and continued until the end of pneumoperitoneum a
Sponsors
Uttar Pradesh University Of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ASA I and II scheduled for elective laparoscopic cholecystectomy under general anaesthesia
Exclusion criteria
Exclusion criteria: Patient refusal. Patients on chronic opioids. Duration of surgery exceeding 90 minutes Any intraoperative complication involving organs other than the gall bladder (bile duct, liver, diaphragm, stomach, etc.) Conversion from laparoscopic to open cholecystectomy Intraoperative hemodynamic instability requiring vasopressor support for more than 10 minutes Acute cholecystitis, prior biliary surgery, opioid allergy. Patients with chronic inflammatory disease, opioid dependence, hepatic or renal dysfunction, or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate and compare the effects of intraoperative remifentanil based and fentanyl based anaesthesia on postoperative inflammatory stress markers namely interleukin 6 and C reactive protein. Timepoint: Baseline in preoperative period and then at 6 hours postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery & NRS pain scoreTimepoint: In preoperative period & at 6hour postoperatively | — |
Countries
India
Contacts
Public ContactDr Himanshu Prince
Uttar Pradesh University of Medical Sciences, Saifai,Etawah
Outcome results
None listed