Health Condition 1: G439- Migraine, unspecified
Conditions
Interventions
Intervention1: Low dose pilocarpine in tear substitute: 0.125% pilocarpine ophthalmic solution eye drops twice daily for 3 months
Control Intervention1: Tear substitute: Tear substitute eye drops twic
Sponsors
Ruby Moharana
Eligibility
Inclusion criteria
Inclusion criteria: Participants meeting ICHD 3 criteria for migraine Participants 12 to 40 years old with migraine and photophobia Participants having light as a trigger factor for the migraine attack Participants with best corrected visual acuity 6 by 6 for distance and N6 for near Participants with normal anterior and posterior segments with normal Intraocular pressure Participants voluntarily giving informed consent
Exclusion criteria
Exclusion criteria: Participants with pre existing ocular conditions affecting pupil size Participants with Manifest Refraction Spherical Equivalent worse than four diopters of myopia or greater than two diopters of hyperopia in either eye Participants with recent eye surgeries Participants on any medications which can affect pupil size
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Mean change in MMD (Monthly Migraine Days)Timepoint: Baseline, 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores for photophobia and ocular discomfort Timepoint: Baseline, 60 minutes;Photopic Pupil Size in mm by IOL Master 700Timepoint: Baseline, 60 minutes;Tear Break Up time (TBUT)Timepoint: Baseline, 90 days;Headache Impact Test (HIT6) scoresTimepoint: Baseline, 90 days | — |
Countries
India
Contacts
Public ContactRuby Moharana
Apex Eye Care
Outcome results
None listed