A split face comparative study on microneedling for facial pigmentation using Human Placenta extract and tranexamic acid solution

A Prospective spilt face comparative interventional study on the efficacy and safety of Microneedling with Human Placenta extract formulation versus Microneedling with 100mg/ml Tranexamic acid solution in the treatment of melasma

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113684

Enrollment

Registered

2026-07-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Human Placenta Extract: Spilt face study on right side of face. Screening and enrollment followed by 3 sessions of microneedling monthly followed by topical application of Human placent

Eligibility

Inclusion criteria

Inclusion criteria: Treatment Naive patients , willingness to participate , not on topical and oral treatment for melasma

Exclusion criteria

Exclusion criteria: Active acne, Keloidal , Hypertrophic scar, Hematologic risk, Dermatological infections, Pregnancy and Lactation, known allergies

Design outcomes

Primary

Measure	Time frame
To compare the effectiveness of microneedlig combined with topical Human Placenta Extract formulation versus microneedlig combined with Tranexamic acid 100mg/ml in the treatment of melasma, using a split face study designTimepoint: at baseline, 4th week, 8th week final outcome - 12th week	—

Secondary

Measure	Time frame
To compare safety profile of both treatment modalitiesTimepoint: at baseline, 4th week, 8th week final outcome - 12th week;To evaluate dermoscopic improvement in both treated sides using above modalitiesTimepoint: at baseline & final outcome -12th week	—

Countries

India

Contacts

Public ContactDr Bhavana R Doshi

JNMC Belagavi, Nehru Nagar

bhavs1982@gmail.com9422306523

Outcome results