Comparison of Palonosetron 0 point 25 mg versus Palonosetron 0 point 125 mg combined with Dexamethasone 4 mg for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Comparative Study of Efficacy of Palonosetron 0.25mg versus 0.125mg Palonosetron Plus 4mg Dexamethasone in Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113676

Enrollment

120

Registered

2026-07-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Palonosetron 0.125mg plus Dexamethasone 4mg: Palonosetron 0.125mg intravenous plus Dexamethasone 4mg intravenous administered just before induction of anaesthesia in patients undergoing

Eligibility

Inclusion criteria

Inclusion criteria: Age group between 18 to 60 years of both sexes having ASA status I and II undergoing elective laparoscopic cholecystectomy and willing to give informed written consent

Exclusion criteria

Exclusion criteria: Patients unwilling to participate, Patients with history of post operative nausea and vomiting or motion sickness, gastrointestinal motility disorders, hypersensitivity to study drugs, patients on drugs causing nausea and vomiting, diabetes mellitus, ear disease.

Design outcomes

Primary

Measure	Time frame
Incidence of Postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.Timepoint: 30 minutes, 12 hours, 24 hours, 36 hours and 48 hours.	—

Secondary

Measure	Time frame
Hemodynamic changes - heart rate and blood pressureTimepoint: Baseline, Intraoperative, 30 minutes, 12 hours, 24 hours, 36 hours and 48 hours postoperatively;Incidence of adverse effects related to study drugsTimepoint: Up to 48 hours postoperatively;Requirement of rescue antiemetic medicationTimepoint: Within 48 hours postoperatively;Severity of nausea assessed using Visual Analogue ScaleTimepoint: 30 minutes, 12 hours, 24 hours, 36 hours and 48 hours postoperatively	—

Measure

Time frame

Hemodynamic changes - heart rate and blood pressureTimepoint: Baseline, Intraoperative, 30 minutes, 12 hours, 24 hours, 36 hours and 48 hours postoperatively;Incidence of adverse effects related to study drugsTimepoint: Up to 48 hours postoperatively;Requirement of rescue antiemetic medicationTimepoint: Within 48 hours postoperatively;Severity of nausea assessed using Visual Analogue ScaleTimepoint: 30 minutes, 12 hours, 24 hours, 36 hours and 48 hours postoperatively

—

Countries

India

Contacts

Public ContactMd Zamal Ahmad

Rajendra Institute of Medical Sciences

drazizulhaq61@gmail.com9771185861

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026