Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue
Conditions
Interventions
Intervention1: Anthocyanin Rich Blueberry Chitosan Nanoemulgel: Topical application of anthocyanin rich blueberry chitosan nanoemulgel over the oral leukoplakia lesion twice daily for 30 days
Control
Sponsors
Saveetha Dental College and Hospitals
Eligibility
Inclusion criteria
Inclusion criteria: Oral leukoplakia Van der Waal Stage I and Stage II lesions. Patients who have not undergone any previous treatment for oral leukoplakia. Patients willing to provide written informed consent. Patients willing to attend follow up visits at baseline, 15th day and 30th day.
Exclusion criteria
Exclusion criteria: Oral leukoplakia Van der Waal Stage III and Stage IV lesions. Patients with other oral potentially malignant disorders. Patients with histopathological evidence of severe dysplasia or malignancy. Pregnant and lactating women. Patients allergic to anthocyanin, chitosan or tretinoin. Patients with uncontrolled systemic disease or immunocompromised status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in lesion size of oral leukoplakia following treatment with anthocyanin rich blueberry chitosan nanoemulgelTimepoint: Baseline, 15th day, 30th day | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of clinical improvement in oral leukoplakia lesions and evaluation of adverse effects associated with treatment. Timepoint: Baseline, 15th day, 30th day | — |
Countries
India
Contacts
Public ContactDr Sreedevi Dharman
Saveetha Dental College and Hospitals
Outcome results
None listed