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Immediate Lymphatic Reconstruction to Prevent Arm Swelling After Axillary Lymph Node Dissection in Breast Cancer Patients: A Randomized Controlled Trial

Incidence of Breast Cancer Related Lymphedema After Axillary Lymph Node Dissection With and Without Immediate Lymphatic Reconstruction (ILR): A Prospective Comparative Study - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/07/113617
Enrollment
125
Registered
2026-07-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast Health Condition 2: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: lymphaticovenous anastomoses (or lymphatic-lymphatic bridging/lymph node flap): Standard ALND performed per institutional protocol. Immediate lymphatic reconstruction performed duri

Sponsors

SVICCAR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Female patients aged 18 TO 70 years Histologically confirmed breast cancer Planned therapeutic or completion ALND ECOG 0 TO 2 Able to provide informed consent Willing for follow up

Exclusion criteria

Exclusion criteria: Previous ipsilateral axillary surgery Previous axillary radiotherapy Pre-existing ipsilateral arm lymphedema Distant metastatic disease limiting follow up Contraindication to surgery OR anesthesia Life expectancy LESS THAN 2 years BMI MORE THAN 30 kg PER m

Design outcomes

Primary

MeasureTime frame
Incidence of breast cancer related lymphedemaTimepoint: 12 MONTHS—

Secondary

MeasureTime frame
Incidence of BCRL at 18 months Time to onset of BCRL Severity of BCRL Relative limb volume change LYMQOL scores ILR-related complications Surgical morbidity Predictors of BCRL (BMI, age, stage, nodes removed, radiotherapy)Timepoint: 18 MONTHS—

Countries

India

Contacts

Public ContactDr Ratnakar Reddy

Sri Venkateswara Institute of Cancer Care & Advanced Research

drpenumadu@gmail.com9042092936

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026