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Comparison of dexmedetomidine and lignocaine infusions for anaesthesia and pain relief during percutaneous kidney stone surgery

Efficacy and safety of intravenous dexmedetomedine infusion and intravenous lignocaine infusion as an adjuvant to anesthestic agents and analgesia in patients undergoing percutaneous nephrolithotomy PCNL surgery under general anaesthesia: A randomized controlled double blinded study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/07/113595
Enrollment
159
Registered
2026-07-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj. Dexmedetomidine: Inj. Dexmedetomidine 0.5 mcg per kg i.v. over 10 min followed by i.v. infusion at 0.5 mcg per kg per hr Control Intervention1: Inj Lidocaine hydrochloride 2 perc

Sponsors

Geetanjali Medical College and Hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients who will give consent to participate in the study 2.Patients of ASA physical status I and II posted for PCNL surgery under general anaesthesia 3.Patients of either gender, aged 18 to 65 years

Exclusion criteria

Exclusion criteria: Hypersensitivity to the study drugs Body mass index more than 30 kg/m Parturient Significant or major comorbidities - uncontrolled hypertension or diabetes Congestive heart failure Myocardial infarction in the past 6 months Heart block Fixed cardiac output lesions Chronic liver or kidney illness Chronic use of opioids or opioid addiction Patient on antipsychotic drug

Design outcomes

Primary

MeasureTime frame
Induction dose of propofol and intraoperative sevoflurane consumption Requirement of additional analgesic intraoperatively Postoperative analgesia using VAS Time to first rescue analgesia To compare safety in terms of: Perioperative haemodynamics and adverse perioperative eventTimepoint: Vital parameters at baseline, 5 minutes, 10minutes after starting infusion, at the time of intubation , every 5 minutes till 30 minutes and every 10 minutes till end of surgery dose of propofol at the time of induction requirement of total bolus of additional analgesia during surgery Time duration at various dial concentration of sevoflurane Postoperative vas score after immediately shifting to post anaesthesia care unit, at 15 minutes, at 30 minutes then hourly till 8 hours—

Secondary

MeasureTime frame
Secondary objectives To compare and evaluate following parameter in 3 groups: Extubation time Postoperative Ramsay Sedation scale (RSS) Timepoint: Intraoperative Data: Time of extubation and time taken for extubation Postopertaive data: Ramsay Sedation Scale after immediately shifting patient in postoperative care unit, at 15 minutes ,after 30 minutes,after1 hour ,after2 hour—

Countries

India

Contacts

Public ContactAditi Garg

Geetanjali Medical College and Hospitals

drkarunasharma07@gmail.com9610819165

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026