None listed
Conditions
Interventions
Intervention1: Dexmedetomidine: Patients will receive intranasal Dexmedetomidine dose :- 1mcg/kg
Frequency :- once
Route :- intranasal
Control Intervention1: Distilled water: Dose :- 1ml
Frequency :-
Sponsors
Shri Ram Murthi Smarak Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ASA Grade 1 and 2
Exclusion criteria
Exclusion criteria: ASA Grade 3 and 4 Unwillingness to be a part of the trial or patient refusal Allergy to the study drugs Uncontrolled comorbidities [Diabetes mellitus, Hypertension, obese, neurovascular surgeries] and systemic illnesses involving cardiovascular, nervous or respiratory system, any renal or liver disease Hemodynamically unstable patient Pregnancy Anticipated difficult airway / more than 1 attempt / more than 15 seconds for intubation. Body mass Index (BMI) more than 40 kg/m2 Chronic use of opioids/opioid addiction, steroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effect of intranasal dexmedetomidine in attenuating the hemodynamic and stress responses to laryngoscopy and intubation in patients undergoing elective surgical procedures under general anaesthesia.Timepoint: Baseline (prior to intranasal administration) 5 min Post intranasal administration 10 min Post intranasal administration Immediate Post induction 1 min Post induction 2 min Post induction 3 min Post induction 4 min Post induction 5 min Post induction 6 min Post induction 7 min Post induction 8 min Post induction 9 min Post induction 10 min Post induction hemodynamic and stress responses to laryngoscopy and intubation in patients undergoing elective surgical procedures under general anaesthesia. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effect of intranasal dexmedetomidine (1 mcg/kg) on hemodynamic responses (HR and BP) and stress response to laryngoscopy and intubation.Timepoint: Baseline (prior to intranasal administration) 5 min Post intranasal administration 10 min Post intranasal administration Immediate Post induction 1 min Post induction 2 min Post induction 3 min Post induction 4 min Post induction 5 min Post induction 6 min Post induction 7 min Post induction 8 min Post induction 9 min Post induction 10 min Post induction;To analyze the influence of intranasal dexmedetomidine (1 mcg/kg) on myocardial oxygen demand.Timepoint: Baseline (prior to intranasal administration) 5 min Post intranasal administration 10 min Post intranasal administration Immediate Post induction 1 min Post induction 2 min Post induction 3 min Post induction 4 min Post induction 5 min Post induction 6 min Post induction 7 min Post induction 8 min Post induction 9 min Post induction 10 min Post induction;To compare with the effects of intranasal dexmedetomidine (1mcg/kg) hemodynamic stress response to laryngoscopy and endotracheal intubation compared to placebo or standard premedication.Timepoint: Baseline (prior to intranasal administration) 5 min Post intranasal administration 10 min Post intranasal administration Immediate Post induction 1 min Post induction 2 min Post induction 3 min Post induction 4 min Post induction 5 min Post induction 6 min Post induction 7 min Post induction 8 min Post induction 9 min Post induction 10 min Post induction;To observe and document any adverse effects or events associated with intranasal dexmedetomidine administration.Timepoint: Baseline (prior to intranasal administration) 5 min Post intranasal administration 10 min Post intranasal administration Immediate Post induction 1 mi | — |
Countries
India
Contacts
Public ContactDr Ashita Mowar
Shri Ram Murthi Smarak Institute of Medical Sciences
Outcome results
None listed