A study comparing tooth pain after placing three different intracanal medicaments in patients with symptomatic apical periodontitis.

Comparative Assessment Of Postoperative Pain In Symptomatic Apical Periodontitis After Use Of Three Different Intracanal Medicaments: A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113588

Enrollment

Registered

2026-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Modified triple antibiotic paste, Double antibiotic paste, Single antibiotic paste-Nitrofurantoin: Local administration after 24 hours, 48 hours ,72 hours and 1 week Control Interventio

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy and cooperative patients (ASA 1) 2.A single rooted single canal permanent tooth (anterior and posterior) 3.Teeth with symptomatic apical periodontitis; and 4.Teeth with necrotic pulp that will give a negative response to vitality testing 5.Clinically confirmed by chief complaint of acute pain, tenderness to vertical percussion, lack of response to thermal and electric test 6.Radiographic appearance of periodontal ligament widening or loss of lamina dura on the preoperative radiograph (Periapical Index Score-2 and 3)

Exclusion criteria

Exclusion criteria: 1.Patients taking medicines that could influence pain perception within past 3 months 2.Patients allergic to medications that will be used in the study 3.Non restorable teeth 4.Presence of endo-perio lesions 5.Teeth with acute/chronic apical abscess 6.Teeth with chronic periodontitis 7.Teeth with anatomical difficulties such as open apices 8.Teeth with severe dilacerations 9.Teeth with calcified canals 10.Teeth with internal/external root resorption 11.Teeth with occlusal interferences 12.Patients that had serious medical illness 13.Patients with systemic disorders 14.Patients with immunocompromised diseases such as AIDS or HBV.

Design outcomes

Primary

Measure	Time frame
To compare and assess reduction in postoperative pain after placing three different intracanal medicaments in patients with symptomatic apical periodontitis.Timepoint: Preoperative, At 24 hours , At 48 hours ,At 72 hours and at 1 week	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Mohit Kumar Gunwal

Ranjeet Deshmukh Dental College and Research Centre

dr.mohitgunwal@yahoo.in9175027155

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026