Comparison of two ultrasound-guided pain relief injections after breast surgery to improve postoperative pain control

A randomized controlled study comparing the effect of ultrasound guided erector spinae plane block using bupivacaine alone versus bupivacaine with magnesium sulphate for postoperative analgesia in modified radical mastectomy performed under thoracic segmental spinal anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113563

Enrollment

Registered

2026-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C502- Malignant neoplasm of upper-innerquadrant of breast Health Condition 2: C503- Malignant neoplasm of lower-innerquadrant of breast Health Condition 3: C504- Malignant neoplasm of upper-outerquadrant of breast Health Condition 4: C505- Malignant neoplasm of lower-outerquadrant of breast Health Condition 5: C506- Malignant neoplasm of axillary tail of breast Health Condition 6: C501- Malignant neoplasm of central portion of breast

Interventions

Intervention1: Erector Spinae block: Erector Spinae block in Modified redical mastectomy under thoracic segmental spinal anaesthesia for 24 hrs Control Intervention1: Bupivacaine plus magnesium sulpha

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I-III Willing to provide written informed consent Duration of surgery not more than 2 hrs

Exclusion criteria

Exclusion criteria: Patient refusal Known allergy to local anaesthetics or magnesium sulphate Coagulopathy or on anticoagulants Infection at block site Severe hepatic, renal or cardiac disease BMI more than 35kg per meter square Chronic opioid or analgesic abuse Neurological or psychiatric illness affecting pain assessment Pregnancy or lactation

Design outcomes

Primary

Measure	Time frame
Duration of analgesiaTimepoint: Duration of analgesia 0,2,4,6,8,12 and 24 hr post op	—

Secondary

Measure	Time frame
Pain scores using VAS/NRSTimepoint: At 0,2,4,6,8,10,12,24 hrs postoperatively;Time to first rescue analgesicTimepoint: At 0,2,4,6,8,10,12 and 24hrs postoperatively;Total rescue analgesic consumptionTimepoint: Within first 24 hours postoperatively;Postoperative hemodynamic parametersTimepoint: At 0,2,4,6,8,10,12 and 24 hours;Incidence of nausea, vomiting, hypotension, bradycardia and systemic toxicityTimepoint: During 24 hour postoperative period;Block related complications like pain, hematoma, trauma, pneumothorax, neuraxial spreadTimepoint: During 24 hour postoperative period;Patient satisfaction scoreTimepoint: At 24 hours	—

Measure

Time frame

Pain scores using VAS/NRSTimepoint: At 0,2,4,6,8,10,12,24 hrs postoperatively;Time to first rescue analgesicTimepoint: At 0,2,4,6,8,10,12 and 24hrs postoperatively;Total rescue analgesic consumptionTimepoint: Within first 24 hours postoperatively;Postoperative hemodynamic parametersTimepoint: At 0,2,4,6,8,10,12 and 24 hours;Incidence of nausea, vomiting, hypotension, bradycardia and systemic toxicityTimepoint: During 24 hour postoperative period;Block related complications like pain, hematoma, trauma, pneumothorax, neuraxial spreadTimepoint: During 24 hour postoperative period;Patient satisfaction scoreTimepoint: At 24 hours

—

Countries

India

Contacts

Public ContactDr Kiwi Mantan

Sardar Patel Medical College, Bikaner

kiwivyas@gmail.com9929092702

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026