A Study comparing Bone repair technique in gum disease using a bone filler and antibiotic root treatment,with and without a natural healing membrane.

COMPARATIVE EVALUATION OF NANOCRYSTALLINE HYDROXYAPATITE BONE GRAFT AND TETRACYCLINE ROOT BIOMODIFICATION WITH AND WITHOUT AUTOLOGOUS PLATELET-RICH FIBRIN IN THE TREATMENT OF INTRABONY DEFECTS. - PRF

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113485

Enrollment

Registered

2026-07-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Nanocrystalline Hydroxyapatite Bone Graft: Nano crystalline hydroxyapatite bone graft has been used for augmentation procedures in intrabony defects. Control Intervention1: PLATELET RIC

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients in good systemic health with no contraindication for periodontal surgery. 2. Patient with chronic periodontitis. 3. Single-rooted teeth or multi-rooted teeth without furcation involvement having at least one site associated with an intrabony defect of more then equal to 4 mm involving predominantly the interdental space of the tooth.

Exclusion criteria

Exclusion criteria: 1. Patients with uncontrolled or poorly controlled Diabetes, unstable or life threatening conditions. 2. History of long term use of medications (Immunosuppressants and Antibiotics). 3. Subjects are Allergic to medications. 4. Pregnant or Lactating women. 5. Smokers or those who used any Tobacco products. 6. Subjects showing Unacceptable Oral Hygiene Maintenance after Initial Phase I therapy. 7. Undergone Periodontal Surgery in past 6 months.

Design outcomes

Primary

Measure	Time frame
Clinical attachment level gain. Radiographic bone fill.Timepoint: baseline(0 month),3 month,6 month.	—

Secondary

Measure	Time frame
Plaque index,Gingival index ,Probing pocket depthTimepoint: baseline(0 month),3 month,6 month	—

Countries

India

Contacts

Public ContactDr Aena Jain Pundir

Rungta College of Dental Sciences and Research Institute

dr.aenajain@gmail.com7000835624

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026