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A Prospective Observational Study on Using the APRI Blood Test Score to Predict Liver Dysfunction in Adult Patients with Sepsis

A Prospective Observational Study on Evaluation of Initial Aspartate Aminotransferase to Platelet Ratio Index APRI Score as a Predictor of Sepsis Induced Liver Dysfunction in Adults - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/07/113483
Enrollment
250
Registered
2026-07-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A419- Sepsis, unspecified organism

Interventions

Intervention1: Nil: Nil

Sponsors

Sri Ramachandra Institute of Higher Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with First ICU Admission

Exclusion criteria

Exclusion criteria: 1. Chronic liver disease 2. Viral hepatitis 3. Hepatic infarction 4. Liver necrosis

Design outcomes

Primary

MeasureTime frame
To identify the Association between the Initial Aspartate Aminotransferase to Platelet ratio index and SALDTimepoint: 1 year—

Secondary

MeasureTime frame
Clinical Association with SALD Subtypes: Evaluate the relationship between initial APRI scores and the development of hypoxic hepatitis versus Sepsis-Induced Cholestasis. Impact on Patient Morbidity and Mortality: Quantify the association between APRI levels and adverse outcomes, specifically all-cause mortality, the incidence of SALD-associated Complications such as SALD-associated Acute Kidney Injury, and the requirement for Renal Replacement TherapyTimepoint: 1 year—

Countries

India

Contacts

Public ContactDr Baby Sailaja K

Sri Ramachandra Institute of Higher Education and Research

sailajaroop@gmail.com9600159482

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026