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Preventing Sore Throat After Surgery by administering Intracuff and Nebulized Ketamine

A COMPARATIVE STUDY TO EVALUATE THE EFFICACY OF INTRACUFF VERSUS NEBULIZED KETAMINE IN PREVENTING POST OPERATIVE SORE THROAT - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/07/113470
Enrollment
94
Registered
2026-07-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: INTRA CUFF KETAMINE ADMINISTRATION: Patients will receive ketamine (50mg) 5 ml in endotracheal tube cuff. Intervention2: NEBULISATION WITH KETAMINE: Patients will receive ketamine (50

Sponsors

Shri Ram Murti Smarak Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-60 years of either sex. 2. American Society of Anaesthesiologist Physical Status I and II. 3. Patients willing to be a part of the study.

Exclusion criteria

Exclusion criteria: 1. Patients refusal or unwillingness to be a part of the study 2. American Society of Anaesthesiologist Physical Status III and IV. 3. Allergy to Ketamine. 4. History of major psychiatric disorder or History of substance abuse. 5. Systemic illnesses involving cardiovascular, nervous or respiratory system, any renal or liver diseases. 6. Hemodynamically unstable patient. 7. Pregnancy 8. Anticipated difficult airway or more than one attempt for intubation.

Design outcomes

Primary

MeasureTime frame
To evaluate the efficacy of intracuff versus nebulized ketamine in preventing post-operative sore throatTimepoint: 0 MIN 1 HOUR 2 HOUR 4 HOUR 8 HOUR 12 HOHR 18 HOUR 24 HOUR—

Secondary

MeasureTime frame
To assess the incidence and severity of postoperative sore throat in patients administered intracuff ketamine.Timepoint: 0 MIN 1 HOUR 2 HOUR 4 HOUR 8 HOUR 12 HOHR 18 HOUR 24 HOUR;To assess the incidence and severity of postoperative sore throat in patients administered ketamine nebulization.Timepoint: 0 MIN 1 HOUR 2 HOUR 4 HOUR 8 HOUR 12 HOHR 18 HOUR 24 HOUR;To compare the incidence and severity of postoperative hoarseness of voice and postoperative cough between both the groups.Timepoint: 0 MIN 1 HOUR 2 HOUR 4 HOUR 8 HOUR 12 HOHR 18 HOUR 24 HOUR;To observe the adverse effects associated with the study drug, if any.Timepoint: 0 MIN 1 HOUR 2 HOUR 4 HOUR 8 HOUR 12 HOHR 18 HOUR 24 HOUR—

Countries

India

Contacts

Public ContactDr Vishwadeep Singh

Shri Ram Murti Smarak Institute of Medical Sciences

vishwadeepvishen@gmail.com9927770078

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026