Oral midodrine for prevention of blood pressure fall during anaesthesia with propofol

Impact of Pre-induction oral midodrine in preventing hypotension during induction of anaesthesia with propofol: a randomised control trial. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113462

Enrollment

Registered

2026-07-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Group M: Preoperative oral midodrine 5mg, administered 120 mins with sips of water before spinal anesthesia.One dose 120 mins prior to induction. Control Intervention1: Group P: Preoper

Eligibility

Inclusion criteria

Inclusion criteria: Patients scheduled for elective non-cardiac surgery under general anaesthesia requiring Propofol for induction American Society of Anesthesiologists physical status I and II Willingness to participate and provide written informed consent

Exclusion criteria

Exclusion criteria: Emergency surgery. Known allergy or contraindication to Midodrine or Propofol. Contraindications to midodrine Patients with a history of significant cardiovascular disease like heart failure, uncontrolled hypertension Patients with renal or hepatic impairment Patients taking medications that may interact with midodrine like alpha-adrenergic agonists, MAO inhibitors Pregnancy or lactation

Design outcomes

Primary

Measure	Time frame
Incidence of hypotension, defined as Systolic blood pressure less than 90 mmHg or a decrease of Mean Arterial Pressure more than 20 percent from baseline in the first 10 minutes following the intravenous administration of Propofol between the oral 5 mg Midodrine group and the placebo group.Timepoint: 2 mins, 4 mins, 6 mins, 8 mins, 10 mins after induction of anaesthesia.	—

Secondary

Measure	Time frame
Severity of hypotension like duration of hypotensive episodes, lowest systolic blood pressure or Mean Arterial Pressure in the first 10 minutes following the intravenous administration of Propofol.Timepoint: 10 mins after induction;Total dose of rescue vasopressors required.Timepoint: 10 mins after induction;Changes in hemodynamic parameters like systolic blood pressure, diastolic blood pressure, heart rate from baselineTimepoint: 3 hrs	—

Measure

Time frame

Severity of hypotension like duration of hypotensive episodes, lowest systolic blood pressure or Mean Arterial Pressure in the first 10 minutes following the intravenous administration of Propofol.Timepoint: 10 mins after induction;Total dose of rescue vasopressors required.Timepoint: 10 mins after induction;Changes in hemodynamic parameters like systolic blood pressure, diastolic blood pressure, heart rate from baselineTimepoint: 3 hrs

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Countries

India

Contacts

Public ContactGANESH RAMAJI NIMJE

AIIMS Gorakhpur

ganesh.nimje8@gmail.com9503332784

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026