Health Condition 1: A150- Tuberculosis of lung
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Dr Shipra Anand
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients diagnosed with pulmonary tuberculosis either microbiologically confirmed or clinically diagnosed according to NTEP guidelines who are malnourished with BMI less than 18.5 for malnourished group and greater than 18.5 for the control group Patients who have been on standard first-line anti TB treatment for at least 2 weeks Patients who can provide informed consent
Exclusion criteria
Exclusion criteria: Pregnant or lactating women Patients with HIV co-infection Patients with multi-drug-resistant TB Patients unable to comply with the study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentrations of isoniazid and rifampicinTimepoint: 2 hours after the last dose of medications, assessed in patients who have been on standard therapy for at least 2 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acetylator phenotype slow, intermediate, or fast assessed via the ration of acetyl isoniazid and isoniazid and NAT2 genotyping.Timepoint: 2 hours after the last dose of medications, assessed in patients who have been on standard therapy for at least 2 weeks. | — |
Countries
India
Contacts
Public ContactDr Shipra Anand
Lok Nayak Hospital, Maulana Azad Medical College
Outcome results
None listed