Comparative efficacy of oral melatonin and Oral Pregabalin as Premedication for attenuation of Hemodynamic response to direct larnygoscopy and endotracheal intubation.

Oral Melatonin Versus Pregabalin: A Premedication Approach to Blunt the Hemodynamic Changes During Airway Instrumentation in Elective Surgical Patient undergoing general anaesthesia, a prospective randomized double blinded study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113426

Enrollment

Registered

2026-07-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Oral Melatonin 6mg: Single dose of oral Melatonin 6mg will be administered 2hrs prior to surgery Intervention2: Oral Pregabalin 150mg: Single Pregabalin 150mg will be administered 2hrs

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1)Patients aged between 18-65 years 2)ASA 1,2 3)Either sex 4)Body mass index greater than 30kg/m 5)Patients undergoing surgeries requiring general anaesthesia

Exclusion criteria

Exclusion criteria: 1)patients with difficult airway 2)patient requiring more than 1 attempt at intubation 3)known allergy to drug 4)pregnant and lactating female undergoing emergency surgeries

Design outcomes

Primary

Measure	Time frame
Attenuation of pressor response to direct larnygoscopy and endotrachela intubationTimepoint: Attenuation of pressor response to direct larnygoscopy and endotrachela intubation	—

Secondary

Measure	Time frame
To assess Sedation score between two groups To assess Anxiety score between two groupsTimepoint: 120 mins	—

Countries

India

Contacts

Public ContactDr ANAND S

Chettinad Hospital and research institute

dranandmurugan@gmail.com9444486183

Outcome results