Health Condition 1: F339- Major depressive disorder, recurrent, unspecified
Conditions
Interventions
Intervention1: Ketamine Hydrochloride + Liothyronine Sodium: IV Ketamine hydrochloride 0.5 mg/kg diluted in 100 mL normal saline administered over 40 minutes twice weekly with oral Liothyronine 25 mcg
Sponsors
Shivamogga Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ICD 11 diagnosis of Major Depressive Disorder Patients giving written informed consent
Exclusion criteria
Exclusion criteria: Other psychotic disorders like Schizophrenia, schizoaffective disorder, or current psychotic features Patients with any known hypersensitivity to ketamine or Liothyronine Active substance use disorder past 6 months Uncontrolled hypertension Thyroid disorders hypothyroidism, hyperthyroidism, thyroiditis, or current thyroid hormone supplementation Pregnancy and breastfeeding mothers Osteoporosis, renal hepatic impairment Previous receipt of electroconvulsive therapy or repetitive transcranial magnetic stimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in Hamilton Depression Rating Score (HAM-D) from baseline to Week 4.Timepoint: Week 4 | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of antidepressant response by evaluating time to relapse and maintenance of HAM-D improvement up to Week 12.Timepoint: Week 12.;Response Rates The percentage of patients in each group who achieve a 50 or more reduction in their HAM-D score from where they started.Timepoint: week 12;Remission Rates The percentage of patients in each group whose depression clears up significantly, defined as achieving a HAM-D score of 7 or less.Timepoint: week 12 | — |
Countries
India
Contacts
Public ContactVegi Mahesh Kumar
Shivamogga Institute of Medical Sciences
Outcome results
None listed