This study is to assess whether low-level laser therapy can support better healing of the gums and bone around the teeth after braces are removed, thereby helping to maintain the treatment results and prevent the teeth from shifting back.

Evaluation of the effect of Low-Level Laser Therapy on Bone Density and MMP-9 level During Orthodontic Retention Period: A Single centered, Split mouth, Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113408

Enrollment

Registered

2026-07-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M264- Malocclusion, unspecified

Interventions

Intervention1: Low-level laser therapy + Retainer: Low-level laser therapy uses a low-intensity light to stimulate tissues, promote healing, reduce inflammation, and support bone remodeling Frequency-

Eligibility

Inclusion criteria

Inclusion criteria: Patient visiting the department of orthodontics and successfully completed comprehensive orthodontic treatment (Extraction line of treatment Upper Premolar extraction) Healthy Periodontium

Exclusion criteria

Exclusion criteria: Patients with any bone disorders or any other metabolic diseases. Pregnancy & lactation. Active infection at treatment site. Patients on regular antibiotics, anticoagulants, steroids, or anti-inflammatory drugs.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare changes in bone density between the experimental and control sides after LLLT application in patients during the post-orthodontic retention phaseTimepoint: Baseline,90 days	—

Secondary

Measure	Time frame
To evaluate & compare changes in MMP-9 levels in gingival crevicular fluid between the experimental & control sides after LLLT application in patients during the post-orthodontic retention phase. Timepoint: Baseline, 30 days, 90 days	—

Countries

India

Contacts

Public ContactDr Hanumanth S

Vinayaka Missions Sankarachariyar dental college

hanumanth001@gmail.com9003425955

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026