Comparing two modes of ventilator breathing in spine cancer patients

Comparison of Pressure Control Mode versus the new Volume Control Autoflow Mode for mechanical ventilation in oncosurgical patients in prone position

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113406

Enrollment

Registered

2026-07-06

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Volume Control Autoflow mode of ventilation: Patient shall be mechanically ventilated using a tidal volume of 7ml/kg and positive end expiratory pressure of 5mmHg after switching the ve

Eligibility

Inclusion criteria

Inclusion criteria: Weight 40-80kg ASA I-III Undergoing oncosurgery in prone position

Exclusion criteria

Exclusion criteria: Non consent Asthma Chronic Obstructive Airway Disease

Design outcomes

Primary

Measure	Time frame
Dynamic complianceTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation	—

Secondary

Measure	Time frame
Heart rateTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Mean arterial pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;End tidal carbon di oxideTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Mean Airway pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Peak inspiratory pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Plateau airway pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Respiratory rateTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Tidal VolumeTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Minute ventilationTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Airway resistanceTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Arterial blood oxygen saturationTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Arterial blood carbon di oxide saturationTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Serum sodiumTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Serum potassiumTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Serum calciumTimepoint: Measured at ba	—

Measure

Time frame

Heart rateTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Mean arterial pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;End tidal carbon di oxideTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Mean Airway pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Peak inspiratory pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Plateau airway pressureTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Respiratory rateTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Tidal VolumeTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Minute ventilationTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Airway resistanceTimepoint: Measured at 30 minutes, 60 minutes and 90 minutes after starting each mode of ventilation;Arterial blood oxygen saturationTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Arterial blood carbon di oxide saturationTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Serum sodiumTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Serum potassiumTimepoint: Measured at baseline, 90 minutes after volume control ventilation, 90 minutes after pressure control ventilation and 90 minutes after autoflow ventilation;Serum calciumTimepoint: Measured at ba

—

Countries

India

Contacts

Public ContactDr Shagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, Rohini, Delhi

drshagun_2010@rediffmail.com09891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026