Health Condition 1: I340- Nonrheumatic mitral (valve) insufficiency Health Condition 2: I059- Rheumatic mitral valve disease, unspecified
Conditions
Interventions
Intervention1: Infusion of Inj. Ketamine at 1mg/kg/hour to group A.: Infusion of Inj. Ketamine at 1mg/kg/hour from the start of surgery till six hour post operative period or until the patient is put
Sponsors
UN Mehta Institute of Cardiology and Research Centre
Eligibility
Inclusion criteria
Inclusion criteria: Consenting patients of both sexes undergoing Valvular surgery between the age of 20 years to 70 years.
Exclusion criteria
Exclusion criteria: Patients less than 20 years or more than 70 years. Patients undergoing Double Valve Replacement, patients having fever in the past two week, patients with elevated baseline markers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the antiinflammatory impact of intravenous ketamine on levels of CRP, IL6 and the neutrophil to lymphocyte ratio.Timepoint: At baseline, 24 hour and 48 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the difference in the ionotropic requirement between two groups. To determine the need for vasopressors and the incidence of vasoplegia between two groups. To compare pain scores and opoid requirement between two groups. To compare early postoperative outcome with respect to Ventilation Duration, ICU Stay, and hospital stay. Timepoint: At baseline, 24 hour, 48 hour. | — |
Countries
India
Contacts
Public ContactBhawana Sharma
UN Mehta Institute of Cardiology and Research Centre
Outcome results
None listed