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To assess the treatment outcome (hsCRP and IL-6 levels) in patients with endodontic and periodontal lesions following root canal treatment

Estimation of serum inflammatory marker levels in different grades of endo perio lesion in systemically healthy patients A prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/07/113385
Enrollment
50
Registered
2026-07-03
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Vaishnavi Devi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients in the age group of 20-60 years with no systemic disease. The inclusion criteria for each group - Control group - Patients diagnosed with no teeth having clinical and radiographic evidence of caries/cracks/fracture Primary endodontic lesion group - Patients having a single tooth diagnosed with pulp necrosis with symptomatic/asymptomatic chronic apical periodontitis, with delayed/no response to pulp sensibility tests and PAI score greater than or equal to 3 Combined endo-perio lesion group - Patients having a single tooth diagnosed with chronic periodontitis and having at least one non vital tooth with concurrent endodontic periodontal lesion with apical radiolucency along with communication through periodontal pocket Primary periodontal lesion group - Patients having a single tooth diagnosed with chronic periodontitis with no clinical and radiographic evidence of cracks/caries.

Exclusion criteria

Exclusion criteria: Patients with acute/chronic systemic disease, recent hospitalization within the last 6 months, patients undertaking drug therapy for other systemic illness, immunosuppressant, estrogen therapy and NSAIDs, antibiotics, corticosteroids, statins, selective serotonin uptake inhibitors, bisphosphonates, smokers, pregnant patients, obese patients and history of viral/ bacterial infection within 3 months. Patients with previously endodontically treated teeth with periapical radiolucency, 3rd molars, palatal radicular groove, external cervical resorption, cemental tear and trauma related lesions were excluded in this study to ensure standardization of the included participants

Design outcomes

Primary

MeasureTime frame
To evaluate the serum hsCRP and IL-6 levels in endo perio lesion in systemically healthy patientsTimepoint: 6 months—

Secondary

MeasureTime frame
To compare the baseline and post treatment hsCRP and IL-6 levels in endo perio lesion in systemically healthy patientsTimepoint: 6 months—

Countries

India

Contacts

Public ContactVaishnavi Devi

Meenakshi Ammal Higher education and research

vel9911@yahoo.com7299254666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026