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Comparison of 2 drugs to see the hemodynamic changes with drugs and additional dose of drug requirement

COMPARATIVE EVALUATION OF EFFECT OF VARYING TIME INTERVALS BETWEEN FENTANYL AND PROPOFOL ADMINISTRATION ON PROPOFOL REQUIREMENT FOR INDUCTION OF ANAESTHESIA A RANDOMIZED CONTROL TRIAL - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/07/113314
Enrollment
90
Registered
2026-07-03
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R688- Other general symptoms and signs

Interventions

Intervention1: Fentanyl with propofol: 3 groups- A,B and C Will receive propofol 3 minutes,5 minutes and 7 minutes after fentanyl administration Control Intervention1: Additional propofol requirement

Sponsors

Government medical college Amritsar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients age group between 18-65 years of either sex undergoing elective surgery under general anesthesia 2.American society of anesthesiology grade 1 and 2 3.Duration of Surgery under 2 hours

Exclusion criteria

Exclusion criteria: 1.patient refusal for written consent 2.Allergy to propofol and fentanyl 3.Undergoing emergency surgery 4.presence of cardiovascular, respiratory, hyperthyroidism, hypothyroidism, cerebrovascular disease or renal disease(including hypertension) 5.Anticipated difficult airway 6.History of alcohol and drug abuse

Design outcomes

Primary

MeasureTime frame
To compare the effect of varying time interval between fentanyl and propofol administration on propofol requirement for induction of anesthesiaTimepoint: Randomized group allocation Group A- patients will receive propofol 3 minutes after fentanyl administration Group B - patients will receive propofol 5 minutes after fentanyl administration Group C - patients will receive propofol 7 minutes after fentanyl administration

Secondary

MeasureTime frame
1.Hemodynamics responses in different groups 2.Additional propofol requirement 3.Adverse effect such as hypotension, bradycardiaTimepoint: Total dose of propofol requirement for induction after 3 minutes,5 minutes, 7 minutes & there heart rate,blood pressure changes noted post induction

Countries

India

Contacts

Public ContactDr Anu Sharma

Government medical college Amritsar

anu.anaesthesia.97@gmail.com9814185884

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026